There are some tell-tale signs that it is time to replace your tire would be if you notice the following:
1. White threading wearing through the walls/rims of the tire. See photo below in #2
2. Tire slime/sealant is escaping from the inside of the tire (tire slime in stock Onewheel boards is blue and gooey but can take on different colors). See photo below:
3. The tire constantly needs to be inflated to maintain PSI. Air loss is normal over time, but you shouldn't have to inflate daily
4. Tire tread is flush/level with circular wear indicators (Slick tires only). In the picture below, the tread has not worn down to the indicator level and is in good condition